Assessment of Impact of HLA Type on Outcomes of Allogeneic Hematopoietic Stem Cell Transplantation for Chronic Lymphocytic Leukemia.
Identifieur interne : 001157 ( Main/Exploration ); précédent : 001156; suivant : 001158Assessment of Impact of HLA Type on Outcomes of Allogeneic Hematopoietic Stem Cell Transplantation for Chronic Lymphocytic Leukemia.
Auteurs : Brian T. Hill [États-Unis] ; Kwang Woo Ahn [États-Unis] ; Zhen-Huan Hu [États-Unis] ; Mahmoud Aljurf [Arabie saoudite] ; Amer Beitinjaneh [États-Unis] ; Jean-Yves Cahn [France] ; Jan Cerny [États-Unis] ; Mohamed A. Kharfan-Dabaja [États-Unis] ; Siddhartha Ganguly [États-Unis] ; Nilanjan Ghosh [États-Unis] ; Michael R. Grunwald [États-Unis] ; Yoshihiro Inamoto [Japon] ; Tamila Kindwall-Keller [États-Unis] ; Taiga Nishihori [États-Unis] ; Richard F. Olsson [Suède] ; Ayman Saad [États-Unis] ; Matthew Seftel [Canada] ; Sachiko Seo [Japon] ; Jeffrey Szer [Australie] ; Martin Tallman [États-Unis] ; Celalettin Ustun [États-Unis] ; Peter H. Wiernik [États-Unis] ; Richard T. Maziarz [États-Unis] ; Matt Kalaycio [États-Unis] ; Edwin Alyea [États-Unis] ; Uday Popat [États-Unis] ; Ronald Sobecks [États-Unis] ; Wael Saber [États-Unis]Source :
- Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation [ 1523-6536 ] ; 2017.
Abstract
Chronic lymphocytic leukemia (CLL) is a common hematologic malignancy with many highly effective therapies. Chemorefractory disease, often characterized by deletion of chromosome 17p, has historically been associated with very poor outcomes, leading to the application of allogeneic hematopoietic stem cell transplantation (allo-HCT) for medically fit patients. Although the use of allo-HCT has declined since the introduction of novel targeted therapy for the treatment of CLL, there remains significant interest in understanding factors that may influence the efficacy of allo-HCT, the sole known curative treatment for CLL. The potential benefit of transplantation is most likely due to the presence of alloreactive donor T cells that mediate the graft-versus-leukemia (GVL) effect. The recognition of potentially tumor-specific antigens in the context of class I and II major histocompatibility complex on malignant B lymphocytes by donor T cells may be influenced by subtle differences in the highly polymorphic HLA locus. Given previous reports of specific HLA alleles impacting the incidence of CLL and the clinical outcomes of allo-HCT for CLL, we sought to study the overall survival and progression-free survival of a large cohort of patients with CLL who underwent allo-HCT from fully HLA-matched related and unrelated donors at Center for International Blood and Marrow Transplant Research transplantation centers. We found no statistically significant association of allo-HCT outcomes in CLL based on previously reported HLA combinations. Additional study is needed to further define the immunologic features that portend a more favorable GVL effect after allo-HCT for CLL.
DOI: 10.1016/j.bbmt.2017.10.015
PubMed: 29032274
Affiliations:
- Arabie saoudite, Australie, Canada, France, Japon, Suède, États-Unis
- Alabama, Auvergne-Rhône-Alpes, Caroline du Nord, East Middle Sweden, Floride, Kansas, Massachusetts, Minnesota, Ohio, Oregon, Rhône-Alpes, Région de Kantō, Svealand, Texas, Virginie, Wisconsin, État de New York
- Grenoble, Tokyo, Uppsala
- Université d'Uppsala
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Kharfan-Dabaja</name><affiliation wicri:level="2"><nlm:affiliation>Department of Blood and Marrow Transplantation, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Floride</region></placeName><wicri:cityArea>Department of Blood and Marrow Transplantation, H. Lee Moffitt Cancer Center and Research Institute, Tampa</wicri:cityArea></affiliation></author><author><name sortKey="Ganguly, Siddhartha" sort="Ganguly, Siddhartha" uniqKey="Ganguly S" first="Siddhartha" last="Ganguly">Siddhartha Ganguly</name><affiliation wicri:level="2"><nlm:affiliation>Blood and Marrow Transplantation, Division of Hematology and Oncology, University of Kansas Medical Center, Kansas City, Kansas.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Kansas</region></placeName><wicri:cityArea>Blood and Marrow Transplantation, Division of Hematology and Oncology, University of Kansas Medical Center, Kansas City</wicri:cityArea></affiliation></author><author><name sortKey="Ghosh, Nilanjan" sort="Ghosh, Nilanjan" uniqKey="Ghosh N" first="Nilanjan" last="Ghosh">Nilanjan Ghosh</name><affiliation wicri:level="2"><nlm:affiliation>Department of Hematologic Oncology and Blood Disorders, Levine Cancer Institute, Carolinas Healthcare System, Charlotte, North Carolina.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Caroline du Nord</region></placeName><wicri:cityArea>Department of Hematologic Oncology and Blood Disorders, Levine Cancer Institute, Carolinas Healthcare System, Charlotte</wicri:cityArea></affiliation></author><author><name sortKey="Grunwald, Michael R" sort="Grunwald, Michael R" uniqKey="Grunwald M" first="Michael R" last="Grunwald">Michael R. Grunwald</name><affiliation wicri:level="2"><nlm:affiliation>Department of Hematologic Oncology and Blood Disorders, Levine Cancer Institute, Carolinas Healthcare System, Charlotte, North Carolina.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Caroline du Nord</region></placeName><wicri:cityArea>Department of Hematologic Oncology and Blood Disorders, Levine Cancer Institute, Carolinas Healthcare System, Charlotte</wicri:cityArea></affiliation></author><author><name sortKey="Inamoto, Yoshihiro" sort="Inamoto, Yoshihiro" uniqKey="Inamoto Y" first="Yoshihiro" last="Inamoto">Yoshihiro Inamoto</name><affiliation wicri:level="3"><nlm:affiliation>Division of Hematopoietic Stem Cell Transplantation, National Cancer Center Hospital, Tokyo, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Division of Hematopoietic Stem Cell Transplantation, National Cancer Center Hospital, Tokyo</wicri:regionArea><placeName><settlement type="city">Tokyo</settlement><region type="région">Région de Kantō</region></placeName></affiliation></author><author><name sortKey="Kindwall Keller, Tamila" sort="Kindwall Keller, Tamila" uniqKey="Kindwall Keller T" first="Tamila" last="Kindwall-Keller">Tamila Kindwall-Keller</name><affiliation wicri:level="2"><nlm:affiliation>Division of Hematology/Oncology, University of Virginia Health System, Charlottesville, Virginia.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Virginie</region></placeName><wicri:cityArea>Division of Hematology/Oncology, University of Virginia Health System, Charlottesville</wicri:cityArea></affiliation></author><author><name sortKey="Nishihori, Taiga" sort="Nishihori, Taiga" uniqKey="Nishihori T" first="Taiga" last="Nishihori">Taiga Nishihori</name><affiliation wicri:level="2"><nlm:affiliation>Department of Blood and Marrow Transplantation, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Floride</region></placeName><wicri:cityArea>Department of Blood and Marrow Transplantation, H. Lee Moffitt Cancer Center and Research Institute, Tampa</wicri:cityArea></affiliation></author><author><name sortKey="Olsson, Richard F" sort="Olsson, Richard F" uniqKey="Olsson R" first="Richard F" last="Olsson">Richard F. Olsson</name><affiliation wicri:level="4"><nlm:affiliation>Division of Therapeutic Immunology, Department of Laboratory Medicine, Karolinska Institutet, Stockholm, Sweden; Centre for Clinical Research Sormland, Uppsala University, Uppsala, Sweden.</nlm:affiliation><country xml:lang="fr">Suède</country><wicri:regionArea>Division of Therapeutic Immunology, Department of Laboratory Medicine, Karolinska Institutet, Stockholm, Sweden; Centre for Clinical Research Sormland, Uppsala University, Uppsala</wicri:regionArea><orgName type="university">Université d'Uppsala</orgName><placeName><settlement type="city">Uppsala</settlement><region nuts="1">Svealand</region><region nuts="1">East Middle Sweden</region></placeName></affiliation></author><author><name sortKey="Saad, Ayman" sort="Saad, Ayman" uniqKey="Saad A" first="Ayman" last="Saad">Ayman Saad</name><affiliation wicri:level="2"><nlm:affiliation>Division of Hematology/Oncology, Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Alabama</region></placeName><wicri:cityArea>Division of Hematology/Oncology, Department of Medicine, University of Alabama at Birmingham, Birmingham</wicri:cityArea></affiliation></author><author><name sortKey="Seftel, Matthew" sort="Seftel, Matthew" uniqKey="Seftel M" first="Matthew" last="Seftel">Matthew Seftel</name><affiliation wicri:level="1"><nlm:affiliation>Department of Medical Oncology and Hematology, CancerCare Manitoba, Winnipeg, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Medical Oncology and Hematology, CancerCare Manitoba, Winnipeg</wicri:regionArea><wicri:noRegion>Winnipeg</wicri:noRegion></affiliation></author><author><name sortKey="Seo, Sachiko" sort="Seo, Sachiko" uniqKey="Seo S" first="Sachiko" last="Seo">Sachiko Seo</name><affiliation wicri:level="1"><nlm:affiliation>Department of Hematology and Oncology, National Cancer Research Center East, Chiba, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Hematology and Oncology, National Cancer Research Center East, Chiba</wicri:regionArea><wicri:noRegion>Chiba</wicri:noRegion></affiliation></author><author><name sortKey="Szer, Jeffrey" sort="Szer, Jeffrey" uniqKey="Szer J" first="Jeffrey" last="Szer">Jeffrey Szer</name><affiliation wicri:level="1"><nlm:affiliation>Department of Clinical Haematology and Bone Marrow Transplantation, Royal Melbourne Hospital, Victoria, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Department of Clinical Haematology and Bone Marrow Transplantation, Royal Melbourne Hospital, Victoria</wicri:regionArea><wicri:noRegion>Victoria</wicri:noRegion></affiliation></author><author><name sortKey="Tallman, Martin" sort="Tallman, Martin" uniqKey="Tallman M" first="Martin" last="Tallman">Martin Tallman</name><affiliation wicri:level="2"><nlm:affiliation>Leukemia Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">État de New York</region></placeName><wicri:cityArea>Leukemia Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York</wicri:cityArea></affiliation></author><author><name sortKey="Ustun, Celalettin" sort="Ustun, Celalettin" uniqKey="Ustun C" first="Celalettin" last="Ustun">Celalettin Ustun</name><affiliation wicri:level="2"><nlm:affiliation>Division of Hematology, Oncology, and Transplantation, Department of Medicine, University of Minnesota Medical Center, Minneapolis, Minnesota.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Minnesota</region></placeName><wicri:cityArea>Division of Hematology, Oncology, and Transplantation, Department of Medicine, University of Minnesota Medical Center, Minneapolis</wicri:cityArea></affiliation></author><author><name sortKey="Wiernik, Peter H" sort="Wiernik, Peter H" uniqKey="Wiernik P" first="Peter H" last="Wiernik">Peter H. Wiernik</name><affiliation wicri:level="2"><nlm:affiliation>Our Lady of Mercy Medical Center, Bronx, New York.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">État de New York</region></placeName><wicri:cityArea>Our Lady of Mercy Medical Center, Bronx</wicri:cityArea></affiliation></author><author><name sortKey="Maziarz, Richard T" sort="Maziarz, Richard T" uniqKey="Maziarz R" first="Richard T" last="Maziarz">Richard T. Maziarz</name><affiliation wicri:level="2"><nlm:affiliation>Adult Blood and Marrow Stem Cell Transplant Program, Knight Cancer Institute, Oregon Health and Science University, Portland, Oregon.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Oregon</region></placeName><wicri:cityArea>Adult Blood and Marrow Stem Cell Transplant Program, Knight Cancer Institute, Oregon Health and Science University, Portland</wicri:cityArea></affiliation></author><author><name sortKey="Kalaycio, Matt" sort="Kalaycio, Matt" uniqKey="Kalaycio M" first="Matt" last="Kalaycio">Matt Kalaycio</name><affiliation wicri:level="2"><nlm:affiliation>Cleveland Clinic, Cleveland, Ohio.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Ohio</region></placeName><wicri:cityArea>Cleveland Clinic, Cleveland</wicri:cityArea></affiliation></author><author><name sortKey="Alyea, Edwin" sort="Alyea, Edwin" uniqKey="Alyea E" first="Edwin" last="Alyea">Edwin Alyea</name><affiliation wicri:level="2"><nlm:affiliation>Center of Hematologic Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Massachusetts</region></placeName><wicri:cityArea>Center of Hematologic Oncology, Dana-Farber Cancer Institute, Boston</wicri:cityArea></affiliation></author><author><name sortKey="Popat, Uday" sort="Popat, Uday" uniqKey="Popat U" first="Uday" last="Popat">Uday Popat</name><affiliation wicri:level="2"><nlm:affiliation>M.D. Anderson Cancer Center, Houston, Texas.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Texas</region></placeName><wicri:cityArea>M.D. Anderson Cancer Center, Houston</wicri:cityArea></affiliation></author><author><name sortKey="Sobecks, Ronald" sort="Sobecks, Ronald" uniqKey="Sobecks R" first="Ronald" last="Sobecks">Ronald Sobecks</name><affiliation wicri:level="2"><nlm:affiliation>Cleveland Clinic, Cleveland, Ohio.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Ohio</region></placeName><wicri:cityArea>Cleveland Clinic, Cleveland</wicri:cityArea></affiliation></author><author><name sortKey="Saber, Wael" sort="Saber, Wael" uniqKey="Saber W" first="Wael" last="Saber">Wael Saber</name><affiliation wicri:level="2"><nlm:affiliation>Center for International Blood and Marrow Transplantation and Department of Medicine, Medical College of Wisconsin, Milwaukee, Wisconsin.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Wisconsin</region></placeName><wicri:cityArea>Center for International Blood and Marrow Transplantation and Department of Medicine, Medical College of Wisconsin, Milwaukee</wicri:cityArea></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2017">2017</date><idno type="RBID">pubmed:29032274</idno><idno type="pmid">29032274</idno><idno type="doi">10.1016/j.bbmt.2017.10.015</idno><idno type="wicri:Area/PubMed/Corpus">000375</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000375</idno><idno type="wicri:Area/PubMed/Curation">000373</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000373</idno><idno type="wicri:Area/PubMed/Checkpoint">000373</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000373</idno><idno type="wicri:Area/Ncbi/Merge">005036</idno><idno type="wicri:Area/Ncbi/Curation">005036</idno><idno type="wicri:Area/Ncbi/Checkpoint">005036</idno><idno type="wicri:Area/Main/Merge">001152</idno><idno type="wicri:Area/Main/Curation">001157</idno><idno type="wicri:Area/Main/Exploration">001157</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Assessment of Impact of HLA Type on Outcomes of Allogeneic Hematopoietic Stem Cell Transplantation for Chronic Lymphocytic Leukemia.</title><author><name sortKey="Hill, Brian T" sort="Hill, Brian T" uniqKey="Hill B" first="Brian T" last="Hill">Brian T. Hill</name><affiliation wicri:level="2"><nlm:affiliation>Department of Hematology and Medical Oncology, Cleveland Clinic Taussig Cancer Institute, Cleveland, Ohio. Electronic address: hillb2@ccf.org.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Ohio</region></placeName><wicri:cityArea>Department of Hematology and Medical Oncology, Cleveland Clinic Taussig Cancer Institute, Cleveland</wicri:cityArea></affiliation></author><author><name sortKey="Ahn, Kwang Woo" sort="Ahn, Kwang Woo" uniqKey="Ahn K" first="Kwang Woo" last="Ahn">Kwang Woo Ahn</name><affiliation wicri:level="2"><nlm:affiliation>Center for International Blood and Marrow Transplantation and Department of Medicine, Medical College of Wisconsin, Milwaukee, Wisconsin; Division of Biostatistics, Institute for Health and Society, Medical College of Wisconsin, Milwaukee, Wisconsin.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Wisconsin</region></placeName><wicri:cityArea>Center for International Blood and Marrow Transplantation and Department of Medicine, Medical College of Wisconsin, Milwaukee, Wisconsin; Division of Biostatistics, Institute for Health and Society, Medical College of Wisconsin, Milwaukee</wicri:cityArea></affiliation></author><author><name sortKey="Hu, Zhen Huan" sort="Hu, Zhen Huan" uniqKey="Hu Z" first="Zhen-Huan" last="Hu">Zhen-Huan Hu</name><affiliation wicri:level="2"><nlm:affiliation>Center for International Blood and Marrow Transplantation and Department of Medicine, Medical College of Wisconsin, Milwaukee, Wisconsin.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Wisconsin</region></placeName><wicri:cityArea>Center for International Blood and Marrow Transplantation and Department of Medicine, Medical College of Wisconsin, Milwaukee</wicri:cityArea></affiliation></author><author><name sortKey="Aljurf, Mahmoud" sort="Aljurf, Mahmoud" uniqKey="Aljurf M" first="Mahmoud" last="Aljurf">Mahmoud Aljurf</name><affiliation wicri:level="1"><nlm:affiliation>Department of Oncology, King Faisal Specialist Hospital Center and Research, Riyadh, Saudi Arabia.</nlm:affiliation><country xml:lang="fr">Arabie saoudite</country><wicri:regionArea>Department of Oncology, King Faisal Specialist Hospital Center and Research, Riyadh</wicri:regionArea><wicri:noRegion>Riyadh</wicri:noRegion></affiliation></author><author><name sortKey="Beitinjaneh, Amer" sort="Beitinjaneh, Amer" uniqKey="Beitinjaneh A" first="Amer" last="Beitinjaneh">Amer Beitinjaneh</name><affiliation wicri:level="2"><nlm:affiliation>University of Miami, Miami, Florida.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Floride</region></placeName><wicri:cityArea>University of Miami, Miami</wicri:cityArea></affiliation></author><author><name sortKey="Cahn, Jean Yves" sort="Cahn, Jean Yves" uniqKey="Cahn J" first="Jean-Yves" last="Cahn">Jean-Yves Cahn</name><affiliation wicri:level="3"><nlm:affiliation>Department of Hematology, University Hospital, Grenoble, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Hematology, University Hospital, Grenoble</wicri:regionArea><placeName><region type="region">Auvergne-Rhône-Alpes</region><region type="old region">Rhône-Alpes</region><settlement type="city">Grenoble</settlement></placeName></affiliation></author><author><name sortKey="Cerny, Jan" sort="Cerny, Jan" uniqKey="Cerny J" first="Jan" last="Cerny">Jan Cerny</name><affiliation wicri:level="2"><nlm:affiliation>UMass Memorial Medical Center, Worcester, Massachusetts.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Massachusetts</region></placeName><wicri:cityArea>UMass Memorial Medical Center, Worcester</wicri:cityArea></affiliation></author><author><name sortKey="Kharfan Dabaja, Mohamed A" sort="Kharfan Dabaja, Mohamed A" uniqKey="Kharfan Dabaja M" first="Mohamed A" last="Kharfan-Dabaja">Mohamed A. Kharfan-Dabaja</name><affiliation wicri:level="2"><nlm:affiliation>Department of Blood and Marrow Transplantation, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Floride</region></placeName><wicri:cityArea>Department of Blood and Marrow Transplantation, H. Lee Moffitt Cancer Center and Research Institute, Tampa</wicri:cityArea></affiliation></author><author><name sortKey="Ganguly, Siddhartha" sort="Ganguly, Siddhartha" uniqKey="Ganguly S" first="Siddhartha" last="Ganguly">Siddhartha Ganguly</name><affiliation wicri:level="2"><nlm:affiliation>Blood and Marrow Transplantation, Division of Hematology and Oncology, University of Kansas Medical Center, Kansas City, Kansas.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Kansas</region></placeName><wicri:cityArea>Blood and Marrow Transplantation, Division of Hematology and Oncology, University of Kansas Medical Center, Kansas City</wicri:cityArea></affiliation></author><author><name sortKey="Ghosh, Nilanjan" sort="Ghosh, Nilanjan" uniqKey="Ghosh N" first="Nilanjan" last="Ghosh">Nilanjan Ghosh</name><affiliation wicri:level="2"><nlm:affiliation>Department of Hematologic Oncology and Blood Disorders, Levine Cancer Institute, Carolinas Healthcare System, Charlotte, North Carolina.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Caroline du Nord</region></placeName><wicri:cityArea>Department of Hematologic Oncology and Blood Disorders, Levine Cancer Institute, Carolinas Healthcare System, Charlotte</wicri:cityArea></affiliation></author><author><name sortKey="Grunwald, Michael R" sort="Grunwald, Michael R" uniqKey="Grunwald M" first="Michael R" last="Grunwald">Michael R. Grunwald</name><affiliation wicri:level="2"><nlm:affiliation>Department of Hematologic Oncology and Blood Disorders, Levine Cancer Institute, Carolinas Healthcare System, Charlotte, North Carolina.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Caroline du Nord</region></placeName><wicri:cityArea>Department of Hematologic Oncology and Blood Disorders, Levine Cancer Institute, Carolinas Healthcare System, Charlotte</wicri:cityArea></affiliation></author><author><name sortKey="Inamoto, Yoshihiro" sort="Inamoto, Yoshihiro" uniqKey="Inamoto Y" first="Yoshihiro" last="Inamoto">Yoshihiro Inamoto</name><affiliation wicri:level="3"><nlm:affiliation>Division of Hematopoietic Stem Cell Transplantation, National Cancer Center Hospital, Tokyo, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Division of Hematopoietic Stem Cell Transplantation, National Cancer Center Hospital, Tokyo</wicri:regionArea><placeName><settlement type="city">Tokyo</settlement><region type="région">Région de Kantō</region></placeName></affiliation></author><author><name sortKey="Kindwall Keller, Tamila" sort="Kindwall Keller, Tamila" uniqKey="Kindwall Keller T" first="Tamila" last="Kindwall-Keller">Tamila Kindwall-Keller</name><affiliation wicri:level="2"><nlm:affiliation>Division of Hematology/Oncology, University of Virginia Health System, Charlottesville, Virginia.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Virginie</region></placeName><wicri:cityArea>Division of Hematology/Oncology, University of Virginia Health System, Charlottesville</wicri:cityArea></affiliation></author><author><name sortKey="Nishihori, Taiga" sort="Nishihori, Taiga" uniqKey="Nishihori T" first="Taiga" last="Nishihori">Taiga Nishihori</name><affiliation wicri:level="2"><nlm:affiliation>Department of Blood and Marrow Transplantation, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Floride</region></placeName><wicri:cityArea>Department of Blood and Marrow Transplantation, H. Lee Moffitt Cancer Center and Research Institute, Tampa</wicri:cityArea></affiliation></author><author><name sortKey="Olsson, Richard F" sort="Olsson, Richard F" uniqKey="Olsson R" first="Richard F" last="Olsson">Richard F. Olsson</name><affiliation wicri:level="4"><nlm:affiliation>Division of Therapeutic Immunology, Department of Laboratory Medicine, Karolinska Institutet, Stockholm, Sweden; Centre for Clinical Research Sormland, Uppsala University, Uppsala, Sweden.</nlm:affiliation><country xml:lang="fr">Suède</country><wicri:regionArea>Division of Therapeutic Immunology, Department of Laboratory Medicine, Karolinska Institutet, Stockholm, Sweden; Centre for Clinical Research Sormland, Uppsala University, Uppsala</wicri:regionArea><orgName type="university">Université d'Uppsala</orgName><placeName><settlement type="city">Uppsala</settlement><region nuts="1">Svealand</region><region nuts="1">East Middle Sweden</region></placeName></affiliation></author><author><name sortKey="Saad, Ayman" sort="Saad, Ayman" uniqKey="Saad A" first="Ayman" last="Saad">Ayman Saad</name><affiliation wicri:level="2"><nlm:affiliation>Division of Hematology/Oncology, Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Alabama</region></placeName><wicri:cityArea>Division of Hematology/Oncology, Department of Medicine, University of Alabama at Birmingham, Birmingham</wicri:cityArea></affiliation></author><author><name sortKey="Seftel, Matthew" sort="Seftel, Matthew" uniqKey="Seftel M" first="Matthew" last="Seftel">Matthew Seftel</name><affiliation wicri:level="1"><nlm:affiliation>Department of Medical Oncology and Hematology, CancerCare Manitoba, Winnipeg, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Medical Oncology and Hematology, CancerCare Manitoba, Winnipeg</wicri:regionArea><wicri:noRegion>Winnipeg</wicri:noRegion></affiliation></author><author><name sortKey="Seo, Sachiko" sort="Seo, Sachiko" uniqKey="Seo S" first="Sachiko" last="Seo">Sachiko Seo</name><affiliation wicri:level="1"><nlm:affiliation>Department of Hematology and Oncology, National Cancer Research Center East, Chiba, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Hematology and Oncology, National Cancer Research Center East, Chiba</wicri:regionArea><wicri:noRegion>Chiba</wicri:noRegion></affiliation></author><author><name sortKey="Szer, Jeffrey" sort="Szer, Jeffrey" uniqKey="Szer J" first="Jeffrey" last="Szer">Jeffrey Szer</name><affiliation wicri:level="1"><nlm:affiliation>Department of Clinical Haematology and Bone Marrow Transplantation, Royal Melbourne Hospital, Victoria, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Department of Clinical Haematology and Bone Marrow Transplantation, Royal Melbourne Hospital, Victoria</wicri:regionArea><wicri:noRegion>Victoria</wicri:noRegion></affiliation></author><author><name sortKey="Tallman, Martin" sort="Tallman, Martin" uniqKey="Tallman M" first="Martin" last="Tallman">Martin Tallman</name><affiliation wicri:level="2"><nlm:affiliation>Leukemia Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">État de New York</region></placeName><wicri:cityArea>Leukemia Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York</wicri:cityArea></affiliation></author><author><name sortKey="Ustun, Celalettin" sort="Ustun, Celalettin" uniqKey="Ustun C" first="Celalettin" last="Ustun">Celalettin Ustun</name><affiliation wicri:level="2"><nlm:affiliation>Division of Hematology, Oncology, and Transplantation, Department of Medicine, University of Minnesota Medical Center, Minneapolis, Minnesota.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Minnesota</region></placeName><wicri:cityArea>Division of Hematology, Oncology, and Transplantation, Department of Medicine, University of Minnesota Medical Center, Minneapolis</wicri:cityArea></affiliation></author><author><name sortKey="Wiernik, Peter H" sort="Wiernik, Peter H" uniqKey="Wiernik P" first="Peter H" last="Wiernik">Peter H. Wiernik</name><affiliation wicri:level="2"><nlm:affiliation>Our Lady of Mercy Medical Center, Bronx, New York.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">État de New York</region></placeName><wicri:cityArea>Our Lady of Mercy Medical Center, Bronx</wicri:cityArea></affiliation></author><author><name sortKey="Maziarz, Richard T" sort="Maziarz, Richard T" uniqKey="Maziarz R" first="Richard T" last="Maziarz">Richard T. Maziarz</name><affiliation wicri:level="2"><nlm:affiliation>Adult Blood and Marrow Stem Cell Transplant Program, Knight Cancer Institute, Oregon Health and Science University, Portland, Oregon.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Oregon</region></placeName><wicri:cityArea>Adult Blood and Marrow Stem Cell Transplant Program, Knight Cancer Institute, Oregon Health and Science University, Portland</wicri:cityArea></affiliation></author><author><name sortKey="Kalaycio, Matt" sort="Kalaycio, Matt" uniqKey="Kalaycio M" first="Matt" last="Kalaycio">Matt Kalaycio</name><affiliation wicri:level="2"><nlm:affiliation>Cleveland Clinic, Cleveland, Ohio.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Ohio</region></placeName><wicri:cityArea>Cleveland Clinic, Cleveland</wicri:cityArea></affiliation></author><author><name sortKey="Alyea, Edwin" sort="Alyea, Edwin" uniqKey="Alyea E" first="Edwin" last="Alyea">Edwin Alyea</name><affiliation wicri:level="2"><nlm:affiliation>Center of Hematologic Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Massachusetts</region></placeName><wicri:cityArea>Center of Hematologic Oncology, Dana-Farber Cancer Institute, Boston</wicri:cityArea></affiliation></author><author><name sortKey="Popat, Uday" sort="Popat, Uday" uniqKey="Popat U" first="Uday" last="Popat">Uday Popat</name><affiliation wicri:level="2"><nlm:affiliation>M.D. Anderson Cancer Center, Houston, Texas.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Texas</region></placeName><wicri:cityArea>M.D. Anderson Cancer Center, Houston</wicri:cityArea></affiliation></author><author><name sortKey="Sobecks, Ronald" sort="Sobecks, Ronald" uniqKey="Sobecks R" first="Ronald" last="Sobecks">Ronald Sobecks</name><affiliation wicri:level="2"><nlm:affiliation>Cleveland Clinic, Cleveland, Ohio.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Ohio</region></placeName><wicri:cityArea>Cleveland Clinic, Cleveland</wicri:cityArea></affiliation></author><author><name sortKey="Saber, Wael" sort="Saber, Wael" uniqKey="Saber W" first="Wael" last="Saber">Wael Saber</name><affiliation wicri:level="2"><nlm:affiliation>Center for International Blood and Marrow Transplantation and Department of Medicine, Medical College of Wisconsin, Milwaukee, Wisconsin.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Wisconsin</region></placeName><wicri:cityArea>Center for International Blood and Marrow Transplantation and Department of Medicine, Medical College of Wisconsin, Milwaukee</wicri:cityArea></affiliation></author></analytic><series><title level="j">Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation</title><idno type="eISSN">1523-6536</idno><imprint><date when="2017" type="published">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Chronic lymphocytic leukemia (CLL) is a common hematologic malignancy with many highly effective therapies. Chemorefractory disease, often characterized by deletion of chromosome 17p, has historically been associated with very poor outcomes, leading to the application of allogeneic hematopoietic stem cell transplantation (allo-HCT) for medically fit patients. Although the use of allo-HCT has declined since the introduction of novel targeted therapy for the treatment of CLL, there remains significant interest in understanding factors that may influence the efficacy of allo-HCT, the sole known curative treatment for CLL. The potential benefit of transplantation is most likely due to the presence of alloreactive donor T cells that mediate the graft-versus-leukemia (GVL) effect. The recognition of potentially tumor-specific antigens in the context of class I and II major histocompatibility complex on malignant B lymphocytes by donor T cells may be influenced by subtle differences in the highly polymorphic HLA locus. Given previous reports of specific HLA alleles impacting the incidence of CLL and the clinical outcomes of allo-HCT for CLL, we sought to study the overall survival and progression-free survival of a large cohort of patients with CLL who underwent allo-HCT from fully HLA-matched related and unrelated donors at Center for International Blood and Marrow Transplant Research transplantation centers. We found no statistically significant association of allo-HCT outcomes in CLL based on previously reported HLA combinations. Additional study is needed to further define the immunologic features that portend a more favorable GVL effect after allo-HCT for CLL.</div></front></TEI><affiliations><list><country><li>Arabie saoudite</li><li>Australie</li><li>Canada</li><li>France</li><li>Japon</li><li>Suède</li><li>États-Unis</li></country><region><li>Alabama</li><li>Auvergne-Rhône-Alpes</li><li>Caroline du Nord</li><li>East Middle Sweden</li><li>Floride</li><li>Kansas</li><li>Massachusetts</li><li>Minnesota</li><li>Ohio</li><li>Oregon</li><li>Rhône-Alpes</li><li>Région de Kantō</li><li>Svealand</li><li>Texas</li><li>Virginie</li><li>Wisconsin</li><li>État de New York</li></region><settlement><li>Grenoble</li><li>Tokyo</li><li>Uppsala</li></settlement><orgName><li>Université d'Uppsala</li></orgName></list><tree><country name="États-Unis"><region name="Ohio"><name sortKey="Hill, Brian T" sort="Hill, Brian T" uniqKey="Hill B" first="Brian T" last="Hill">Brian T. Hill</name></region><name sortKey="Ahn, Kwang Woo" sort="Ahn, Kwang Woo" uniqKey="Ahn K" first="Kwang Woo" last="Ahn">Kwang Woo Ahn</name><name sortKey="Alyea, Edwin" sort="Alyea, Edwin" uniqKey="Alyea E" first="Edwin" last="Alyea">Edwin Alyea</name><name sortKey="Beitinjaneh, Amer" sort="Beitinjaneh, Amer" uniqKey="Beitinjaneh A" first="Amer" last="Beitinjaneh">Amer Beitinjaneh</name><name sortKey="Cerny, Jan" sort="Cerny, Jan" uniqKey="Cerny J" first="Jan" last="Cerny">Jan Cerny</name><name sortKey="Ganguly, Siddhartha" sort="Ganguly, Siddhartha" uniqKey="Ganguly S" first="Siddhartha" last="Ganguly">Siddhartha Ganguly</name><name sortKey="Ghosh, Nilanjan" sort="Ghosh, Nilanjan" uniqKey="Ghosh N" first="Nilanjan" last="Ghosh">Nilanjan Ghosh</name><name sortKey="Grunwald, Michael R" sort="Grunwald, Michael R" uniqKey="Grunwald M" first="Michael R" last="Grunwald">Michael R. Grunwald</name><name sortKey="Hu, Zhen Huan" sort="Hu, Zhen Huan" uniqKey="Hu Z" first="Zhen-Huan" last="Hu">Zhen-Huan Hu</name><name sortKey="Kalaycio, Matt" sort="Kalaycio, Matt" uniqKey="Kalaycio M" first="Matt" last="Kalaycio">Matt Kalaycio</name><name sortKey="Kharfan Dabaja, Mohamed A" sort="Kharfan Dabaja, Mohamed A" uniqKey="Kharfan Dabaja M" first="Mohamed A" last="Kharfan-Dabaja">Mohamed A. Kharfan-Dabaja</name><name sortKey="Kindwall Keller, Tamila" sort="Kindwall Keller, Tamila" uniqKey="Kindwall Keller T" first="Tamila" last="Kindwall-Keller">Tamila Kindwall-Keller</name><name sortKey="Maziarz, Richard T" sort="Maziarz, Richard T" uniqKey="Maziarz R" first="Richard T" last="Maziarz">Richard T. Maziarz</name><name sortKey="Nishihori, Taiga" sort="Nishihori, Taiga" uniqKey="Nishihori T" first="Taiga" last="Nishihori">Taiga Nishihori</name><name sortKey="Popat, Uday" sort="Popat, Uday" uniqKey="Popat U" first="Uday" last="Popat">Uday Popat</name><name sortKey="Saad, Ayman" sort="Saad, Ayman" uniqKey="Saad A" first="Ayman" last="Saad">Ayman Saad</name><name sortKey="Saber, Wael" sort="Saber, Wael" uniqKey="Saber W" first="Wael" last="Saber">Wael Saber</name><name sortKey="Sobecks, Ronald" sort="Sobecks, Ronald" uniqKey="Sobecks R" first="Ronald" last="Sobecks">Ronald Sobecks</name><name sortKey="Tallman, Martin" sort="Tallman, Martin" uniqKey="Tallman M" first="Martin" last="Tallman">Martin Tallman</name><name sortKey="Ustun, Celalettin" sort="Ustun, Celalettin" uniqKey="Ustun C" first="Celalettin" last="Ustun">Celalettin Ustun</name><name sortKey="Wiernik, Peter H" sort="Wiernik, Peter H" uniqKey="Wiernik P" first="Peter H" last="Wiernik">Peter H. Wiernik</name></country><country name="Arabie saoudite"><noRegion><name sortKey="Aljurf, Mahmoud" sort="Aljurf, Mahmoud" uniqKey="Aljurf M" first="Mahmoud" last="Aljurf">Mahmoud Aljurf</name></noRegion></country><country name="France"><region name="Auvergne-Rhône-Alpes"><name sortKey="Cahn, Jean Yves" sort="Cahn, Jean Yves" uniqKey="Cahn J" first="Jean-Yves" last="Cahn">Jean-Yves Cahn</name></region></country><country name="Japon"><region name="Région de Kantō"><name sortKey="Inamoto, Yoshihiro" sort="Inamoto, Yoshihiro" uniqKey="Inamoto Y" first="Yoshihiro" last="Inamoto">Yoshihiro Inamoto</name></region><name sortKey="Seo, Sachiko" sort="Seo, Sachiko" uniqKey="Seo S" first="Sachiko" last="Seo">Sachiko Seo</name></country><country name="Suède"><region name="Svealand"><name sortKey="Olsson, Richard F" sort="Olsson, Richard F" uniqKey="Olsson R" first="Richard F" last="Olsson">Richard F. Olsson</name></region></country><country name="Canada"><noRegion><name sortKey="Seftel, Matthew" sort="Seftel, Matthew" uniqKey="Seftel M" first="Matthew" last="Seftel">Matthew Seftel</name></noRegion></country><country name="Australie"><noRegion><name sortKey="Szer, Jeffrey" sort="Szer, Jeffrey" uniqKey="Szer J" first="Jeffrey" last="Szer">Jeffrey Szer</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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